Cynomolgus B7-H2 / ICOSLG Protein, His Tag, Unconjugated, Human
Artikelnummer:
ABS-B72-C52HB-100UG
Hersteller Artikelnummer:
B72-C52Hb-100ug
Alternativnummer:
ABS-B72-C52HB-100UG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Monkey
Konjugation:
Unconjugated
ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7H2), B7related protein 1 (B7RP1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Iglike C2type (immunoglobulinlike) domain and one Iglike Vtype (immunoglobulinlike) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7H2 is ligand for the Tcellspecific cell surface receptor ICOS. B7H2 acts as a costimulatory signal for Tcell proliferation and cytokine secretion and induces also Bcell proliferation and differentiation into plasma cells. B7H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by costimulating memory Tcell function. - Proteine/Peptide
