SMUG1 Antibody, Rabbit, Polyclonal

Produktübersicht

• Artikelname: SMUG1 Antibody, Rabbit, Polyclonal
• Artikelnummer: ABT-AP51894
• Hersteller Artikelnummer: AP51894
• Alternativnummer: ABT-AP51894-100UL
• Hersteller: Abcepta
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Human, Mouse, Rat
• Alternative Synonym: Single-strand selective monofunctional uracil DNA glycosylase, 322-, SMUG1

Produktbeschreibung

Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5- hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. The general order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at the low salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA.

Produkteigenschaften

• Klonalität: Polyclonal
• NCBI: 23583
• UniProt: Q53HV7