AML1 (Phospho-Ser435) Antibody, Rabbit, Polyclonal

Produktübersicht

• Artikelname: AML1 (Phospho-Ser435) Antibody, Rabbit, Polyclonal
• Artikelnummer: ABT-AP52566
• Hersteller Artikelnummer: AP52566
• Alternativnummer: ABT-AP52566-100UL
• Hersteller: Abcepta
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: WB
• Alternative Synonym: Runt-related transcription factor 1, Acute myeloid leukemia 1 protein, Core-binding factor subunit alpha-2, CBF-alpha-2, Oncogene AML-1, Polyomavirus enhancer-binding protein 2 alpha B subunit, PEA2-alpha B, PEBP2-alpha B, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit, RUNX1, AML1, CBFA2

Produktbeschreibung

CBF binds to the core site, 5-PYGPYGGT-3, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B- dependent transcriptional activation.

Produkteigenschaften

• Klonalität: Polyclonal
• NCBI: 861
• UniProt: Q01196