TIF1 gamma / TRIM33 Antibody, Mouse, Monoclonal

Produktübersicht

• Artikelname: TIF1 gamma / TRIM33 Antibody, Mouse, Monoclonal
• Artikelnummer: ABT-AP52681
• Hersteller Artikelnummer: AP52681
• Alternativnummer: ABT-AP52681-100UL
• Hersteller: Abcepta
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Human
• Alternative Synonym: 8030451N04Rik,AI413936,cb1085,DKFZp586K1123,E3 ubiquitin-protein ligase TRIM33,EC 6.3.2.-,Ectodermin,Ectodermin homolog,FLJ11429,FLJ32925,id:ibd2175,MGC136680,mKIAA1113, OTTHUMP00000013662,OTTHUMP00000013663,Protein Rfg7,PTC7,Ret fused gene 7,RET-fused gene 7 protein,RFG7,Rfg7 protein,TF1G,TIF1-gamma,TIF1G,TIF1GAMMA,TIFGAMMA,Transcription intermediary factor 1-gamma,Transcriptional intermediary factor 1 gamma,TRI33_HUMAN, Trim33,Tripartite motif containing 33,Tripartite motif containing 33 protein,tripartite motif-containing 33,Tripartite motif-containing protein 33,wu:fc17f10,zgc:136680.

Produktbeschreibung

Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade).

Produkteigenschaften

• Klonalität: Monoclonal
• NCBI: 51592
• UniProt: Q9UPN9