Cyclin D2 Antibody, Mouse, Monoclonal

Produktübersicht

• Artikelname: Cyclin D2 Antibody, Mouse, Monoclonal
• Artikelnummer: ABT-AP52709
• Hersteller Artikelnummer: AP52709
• Alternativnummer: ABT-AP52709-100UL
• Hersteller: Abcepta
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Human
• Alternative Synonym: CCND 2,CCND2,CCND2_HUMAN,CyclinD2,G1/S specific cyclin D2,G1/S-specific cyclin-D2, KIAK0002,MGC102758.

Produktbeschreibung

Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

Produkteigenschaften

• Klonalität: Monoclonal
• NCBI: 894
• UniProt: P30279