DDB1 Antibody, Mouse, Monoclonal
Artikelnummer:
ABT-AP52794
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| Artikelname: | DDB1 Antibody, Mouse, Monoclonal |
| Artikelnummer: | ABT-AP52794 |
| Hersteller Artikelnummer: | AP52794 |
| Alternativnummer: | ABT-AP52794-100UL |
| Hersteller: | Abcepta |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | WB |
| Spezies Reaktivität: | Human, Mouse |
| Alternative Synonym: | Damage specific DNA binding protein 1,Damage-specific DNA-binding protein 1,DDB 1,DDB p127 subunit,Ddb1,DDB1_HUMAN,DDBa ,DNA damage binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein a,HBV X-associated protein 1,UV damaged DNA binding factor,UV damaged DNA binding protein 1,UV DDB 1,UV DDB1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,UV-DDB1,X associated protein 1,XAP 1,XAP-1,XAP1,Xeroderma pigmentosum group E complementing protein,Xeroderma pigmentosum group E-complementing protein,XPCE,XPE,XPE BF,XPE binding factor,XPE-BF,XPE-binding factor. |
| Required for DNA repair. Binds to DDB2 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin- protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2. |
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