Protein Kinase D2 (11C16) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE16531
Produktübersicht
Artikelname:
Protein Kinase D2 (11C16) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE16531
Hersteller Artikelnummer:
AMRe16531
Alternativnummer:
EKL-AMRE16531-50UL, EKL-AMRE16531-100UL, EKL-AMRE16531-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
ICC, IHC, WB
Spezies Reaktivität:
Human, Mouse
Konjugation:
Unconjugated
Alternative Synonym:
HSPC187, nPKC D2, nPKC-D2, PKD2, PRKD 2, Prkd2,
Produktbeschreibung
Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress. Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:15604256, PubMed: 14743217, PubMed: 17077180, PubMed: 16928771, PubMed: 17962809, PubMed: 17951978, PubMed: 18262756, PubMed: 19192391, PubMed: 19001381, PubMed: 23503467, PubMed: 28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed: 15604256, PubMed: 28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed: 17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed: 17077180). During adaptive immune responses, is required in peripheral T- lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed: 16928771). During TCR-induced T- cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed: 19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed: 14743217
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
97kDa
NCBI:
25865
UniProt:
Q9BZL6
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
PRKD2
Anwendungsbeschreibung
Application Verdünnung:
WB 1:500-1:2000,IHC 1:50-1:200,ICC/IF 1:100-1:200
