LZ-07 is a IRAK4 PROTAC degrader (DC50 = 1.14 nM). LZ-07 leads to marked suppression of cytokines including IL-6, IL-1beta, TNF-alpha, and IL-10 upon degradation of IRAK4. LZ-07 can be studied in research for autoimmune diseases (Pink: IRAK4 ligand (HY-172591), Blue: CRBN ligand (HY-34590), Black: linker (HY-B0149), CRBN ligand + linker: HY-172593)[1].
Molekulargewicht:
812.92
Formel:
C42H48N14O4
Target-Kategorie:
Interleukin Related,IRAK,PROTACs,TNF Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
