AITRL, a type II transmembrane protein, is a ligand for glucocorticoid-induced TNFR-related protein (GITR). When AITRL binds to GITR, GITR can produce costimulatory signals that regulate T-cell proliferation and effector functions. GITR/AITRL interaction plays a role in the pathogenesis of tumor, inflammation, as well as autoimmune diseases[1]. Besides, AITRL plays a role in endothelial cells (EC)-activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1, ICAM-1)[2]. AITRL/TNFSF18 Protein, Human is a recombinant human AITRL (E74-I198) without tag, which is expressed in E.coli.
Molekulargewicht:
Approximately 14 kDa, based on SDS-PAGE under reducing conditions.
Reinheit:
95
Formel:
8995(Gene_ID)Q9UNG2 (E52-I176)(Accession)
Anwendungsbeschreibung:
MCE Product type: Recombinant Proteins
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