RET Proto-oncogene Antibody, IgG2c, Clone: [RET/8790], Mouse, Monoclonal

Produktübersicht

• Artikelname: RET Proto-oncogene Antibody, IgG2c, Clone: [RET/8790], Mouse, Monoclonal
• Artikelnummer: NBT-5979-MSM15-P0
• Hersteller Artikelnummer: 5979-MSM15-P0
• Alternativnummer: NBT-5979-MSM15-P0-20
• Hersteller: NeoBiotechnologies
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: IHC
• Spezies Reaktivität: Human
• Immunogen: Recombinant fragment (around aa 702-848) of human RET protein (exact sequence is proprietary)
• Alternative Synonym: Cadherin family member 12 (CDHF12), Cadherin related family member 16 (CDHR16), ELKS, HSCR1, Hydroxyaryl protein kinase, MEN2A, MEN2B, MTC1, Multiple endocrine neoplasia and medullary thyroid carcinoma 1, Oncogene RET, Proto-oncogene c-Ret, Proto-oncogene tyrosine-protein kinase receptor ret, PTC, RET, RET ELE1, RET51, RET9

Produktbeschreibung

The Ret proto-oncogene is structurally related to the growing family of tyrosine kinase transmembrane receptors and is involved in GDNF signaling. RET expression is reported in several regions of the central nervous system, in the developing cranial nerve ganglia and a subset of cells within dorsal root ganglia, in motor neurons in the spinal cord and hindbrain, in neuro-retina and the growing tips of the renal collecting ducts in developing kidney.Alterations in RET OOgene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma, and a congenital developmental disorder known as Hirschsprung s disease.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [RET/8790]
• Molekulargewicht: 150kDa (precursor), 170kDa (Mature)
• Isotyp: IgG2c
• NCBI: 5979
• UniProt: P07949
• Formulierung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Bilder

Formalin-fixed, paraffin-embedded human placenta stained with Purified RET Mouse Monoclonal Antibody (RET/8790). Inset: PBS instead of primary antibody, secondary only negative control.

Formalin-fixed, paraffin-embedded human parathyroid stained with Purified RET Mouse Monoclonal Antibody (RET/8790). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

SDS-PAGE Analysis of Purified RET Mouse Monoclonal Antibody (RET/8790). Confirmation of Purity and Integrity of Antibody.