Zebrafish Ptp4a2 Antibody / Protein tyrosine phosphatase type IVA 2, Rabbit, Polyclonal
Artikelnummer:
NSJ-RZ1072
Hersteller Artikelnummer:
RZ1072
Alternativnummer:
NSJ-RZ1072
Hersteller:
NSJ Bioreagents
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
WB
Spezies Reaktivität:
Zebrafish
Immunogen:
An E.coli-derived zebrafish Ptp4a2 recombinant protein (amino acids M7-D75) was used as the immunogen for the Zebrafish Ptp4a2 antibody.
Protein tyrosine phosphatase type IVA 2 is an enzyme that in humans is encoded by the PTP4A2 gene. The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17.
