Zebrafish Hras Antibody / Isoforms a & b, Rabbit, Polyclonal
Artikelnummer:
NSJ-RZ1080
Hersteller Artikelnummer:
RZ1080
Alternativnummer:
NSJ-RZ1080
Hersteller:
NSJ Bioreagents
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IHC-P, WB
Spezies Reaktivität:
Zebrafish
Immunogen:
An E.coli-derived zebrafish Hrasa/b recombinant protein (amino acids K101-S177) was used as the immunogen for the Zebrafish Hras antibody. This antibody will detect the a and b isoforms.
GTPase HRas, also known as transforming protein p21, is an enzyme that in humans is encoded by the HRAS gene. This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.
