An E.coli-derived zebrafish SMARCB1a/b recombinant protein (amino acids E93-D346) was used as the immunogen for the Zebrafish Smarcb1 antibody. This antibody will detect the a and b isoforms.
Predicted to enable DNA binding activity and transcription coactivator activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to be located in nuclear chromosome. Predicted to be part of brahma complex, nBAF complex, and npBAF complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 3, meningioma, rhabdoid cancer, rhabdoid tumor predisposition syndrome 1, and schwannomatosis (multiple). Orthologous to human SMARCB1 (SWI/SNF related BAF chromatin remodeling complex subunit B1).
