EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner. EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase).
Molekulargewicht:
368.34
Reinheit:
95.16%
CAS Nummer:
[1808714-73-9]
Formel:
C19H14F2N4O2
Target-Kategorie:
Proton pump|||Autophagy
T11191
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