Biotinylated Recombinant Human IL-21 Protein, E. coli
Biozol Catalog Number:
ABB-RP03516B
Supplier Catalog Number:
RP03516B
Alternative Catalog Number:
ABB-RP03516B-100UG
Manufacturer:
ABclonal
Host:
E. coli
Category:
Proteine/Peptide
Species Reactivity:
Human
Immunogen:
Gln32-Ser162
Alternative Names:
Interleukin-21, IL-21, Za11,IL21
IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. IL21 is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. It may promote the transition between innate and adaptive immunity. IL-21 has been tried as a therapy for alleviating allergic responses. It can significantly decrease pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation).
Lyophilized from 0.22 µm filtered solution in 20mM NaAc, 500mM NaCl (pH 5.5). Normally 8% trehalose is added as protectant before lyophilization.
Application Notes:
Cross-Reactivity: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 µg/ml is recommended. Dissolve the lyophilized protein in 20mM NaAc,500mM NaCl (pH 5.5). ResearchArea: Interleukin,Cell Culture related,Biosimilar Drug Targets
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