HUR Antibody, Rabbit, Polyclonal

Product Overview

• Article Name: HUR Antibody, Rabbit, Polyclonal
• Biozol Catalog Number: ABT-AP52000
• Supplier Catalog Number: AP52000
• Alternative Catalog Number: ABT-AP52000-100UL
• Manufacturer: Abcepta
• Host: Rabbit
• Category: Antikörper
• Application: WB
• Species Reactivity: Human
• Alternative Names: ELAV-like protein 1, Hu-antigen R, HuR, ELAVL1, HUR

Product Description

Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5- UUUU[AG]UUU-3 motif in vitro. With ZNF385A, binds the 3-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA.

Product Properties

• Clonality: Polyclonal
• NCBI: 1994
• UniProt: Q15717