Cyclin D3 (Phospho-Thr283) Antibody, Rabbit, Polyclonal
Catalog Number:
ABT-AP52373
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| Article Name: | Cyclin D3 (Phospho-Thr283) Antibody, Rabbit, Polyclonal |
| Biozol Catalog Number: | ABT-AP52373 |
| Supplier Catalog Number: | AP52373 |
| Alternative Catalog Number: | ABT-AP52373-100UL |
| Manufacturer: | Abcepta |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | IHC, WB |
| Species Reactivity: | Human, Mouse, Rat |
| Alternative Names: | G1/S-specific cyclin-D3, CCND3 |
| Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. |
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