MS154 is a first-in-class E3 ligase cereblon-recruited EGFR degrader with Kd values of 1.8 nM and 3.8 nM for EGFR WT and EGFR L858R mutant, respectively. MS154 potently induces degradation of mutant, but not wild-type, EGFR in cancer cell lines in an E3 ligase-dependent manner. MS154 exhibits anticancer effects against lung cancer (blue: E3 ligase ligand (HY-103596), black: linker (HY-W096167), pink: EGFR ligand (HY-168305))[1].
Molecular Weight:
901.42
Purity:
99.71
CAS Number:
[2550393-21-8]
Formula:
C46H54ClFN8O8
Target:
EGFR,PROTACs
Application Notes:
MCE Product type: Reference compound
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