IMM-H007 (WS070117) is an orally active and potent AMPK (AMP-activated protein kinase) activator and TGFbeta1 (transforming growth factor beta1) antagonist. IMM-H007 has protective effects in cardiovascular diseases via activation of AMPK. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-kappaB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 degradation. IMM-H007 resolves hepatic steatosis in HFD-fed hamsters by the regulation of lipid metabolism. IMM-H007 can be used for the research of nonalcoholic fatty liver disease (NAFLD) and inflammatory atherosclerosis[1][2][3].
Molecular Weight:
485.45
Purity:
97.69
CAS Number:
[1221412-23-2]
Formula:
C22H23N5O8
Target:
AMPK,AP-1,JNK,NF-kappaB,TGF-beta Receptor
Application Notes:
MCE Product type: Reference compound
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