L134 is a potent PROTAC BRD4 degrader with a DC50 value of 7.36 nM. L134 mediates the degradation of BRD4 via the ubiquitin-proteasome system in a DCAF11-dependent manner (Blue: JQ-1 (carboxylic acid) (HY-78695), Black: linker (HY-W004640), Pink: E3 ligase ligand, L321 (HY-169359))[1].
Molecular Weight:
962.47
Formula:
C48H51ClF3N7O7S
Target:
Epigenetic Reader Domain,PROTACs
Application Notes:
Reference compound
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