IL-1R1 (CD121a) belongs to IL-1 receptor, and binds to IL-1alpha, IL-1beta, IL-1Ra and IL-38 with comparable affinities (Kd: 0.1-1 nM)[1]. IL-1R1 regulates the transcription of multiple proinflammatory cytokines and mediates immune and inflammatory responses, including the activation of NF-kappaB and MAPK pathway[4]. IL-1R1 Protein, Human (HEK293, Fc) is a recombinant human extracellular region of IL-1R1 (M1-T332) with a C-Terminal hFc tag, which is produced in HEK293 cells.
Molecular Weight:
Approximately 80-90 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
Formula:
3554(Gene_ID)P14778 (L18-T332)(Accession)
Application Notes:
MCE Product type: Recombinant Proteins
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