IL-23R Protein, critical in immune response, forms the interleukin-23 receptor by associating with IL12RB1. Binding to IL23, it activates T-cells, NK cells, and potentially macrophage/myeloid cells through Jak-Stat signaling. Associated with autoimmune diseases and tumorigenesis, IL-23R, in the presence of IL12RB1, forms a heterodimeric IL-23 receptor, interacting with JAK2 and activating STAT3. IL-23R Protein, Rat (HEK293, Fc) is the recombinant rat-derived IL-23R protein, expressed by HEK293 , with C-hFc labeled tag.
Molecular Weight:
Approximately 90-120 kDa, based on SDS-PAGE under reducing conditions.
