mPEG-Mal (MW 5000), CAS [[724722-89-8]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-W020780
Supplier Catalog Number:
HY-W020780
Alternative Catalog Number:
MCE-HY-W020780-50MG,MCE-HY-W020780-100MG
Manufacturer:
MedchemExpress
Category:
Kits/Assays
Alternative Names:
mPEG-Maleimide (MW 5000)
mPEG-Mal (mPEG-Maleimide) (MW 5000) is a PEG-derived selective covalent binding agent for sulfhydryl groups (RSGs), which can form irreversible thioether bonds with sulfhydryl groups under near-neutral conditions via the maleimide group. The mechanism of action of mPEG-Mal (MW 5000) can be divided into two categories: firstly, as an enzyme modifier, it binds to target proteins through hydrophobic interactions, hydrogen bonds, and van der Waals forces, altering the proteins secondary structure, secondly, as a nanoparticle surface modifier, it covalently binds to sulfhydryl groups on the surface of red blood cells, changing the surface properties and morphology of the red blood cells, leading to their phagocytosis by macrophages of the reticuloendothelial system. mPEG-Mal (MW 5000) can react with free cysteine ??in proteins, increasing the apparent molecular weight of the modified protein by 10-15 kDa for detection purposes. mPEG-Mal (MW 5000) can enhance the thermal stability and catalytic activity of enzymes, and improve the macrophage targeting of nanoparticles, enabling targeted drug delivery. mPEG-Mal (MW 5000) can be applied in enzyme engineering research in the food industry and in oncology, assisting radiotherapy by inhibiting tumor-associated macrophage infiltration and enhancing anti-tumor immune responses[1][2][3][4].
Molecular Weight:
5000 (Average)
Purity:
99.91
CAS Number:
[724722-89-8]
Target:
Biochemical Assay Reagents
Application Notes:
MCE Product type: Biochemical Assay Reagents
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