Recombinant human HPV16 E1/E4 fragment (aa 36-41).
Alternative Names:
cell cycle modulating protein E1 E4, HPV-16 E1-E4, Replication protein E1, Replication protein E4, Human papillomavirus type 16 E1 E4
The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a high-risk sexually-transmitted HPV that can lead to cervical, anal, vulvar, head, neck, and penile cancer. The HPV16E1/E4 protein is expressed abundantly in cells supporting viral DNA amplification but is lost during malignant progression. HPV16E1/E4 causes G2 cell cycle arrest by associating with and preventing the nuclear entry of Cdk1/cyclin B1 complexes. HPV16E1/E4 also interacts with cyclin A and Cdk2 during the G2 phase of the cell cycle, and this association may increase the efficiency with which HPV16E1/E4 is able to prevent mitotic entry. HPV16E1/E4 also associates with keratin intermediate filaments and causes the network to collapse.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Application Notes:
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes), Optimal dilution f
SDS-PAGE Analysis of Purified HPV-18 M
Formalin-fixed, paraffin-embedded human Cervix stained with HPV-16 Mouse Monoclonal Antibody (HPV16 E1/E4).
Formalin-fixed, paraffin-embedded human Cervix stained with HPV-16 Mouse Monoclonal Antibody (HPV16 E1/E4).
SDS-PAGE Analysis of Purified HPV-16 Mouse Monoclonal Antibody (HPV16 E1/E4). Confirmation of Purity and Integrity of Antibody.
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