Zebrafish Jab1 Antibody / Jun activation domain-binding protein 1 / Cops5, Rabbit, Polyclonal
Biozol Catalog Number:
NSJ-RZ1063
Supplier Catalog Number:
RZ1063
Alternative Catalog Number:
NSJ-RZ1063
Manufacturer:
NSJ Bioreagents
Host:
Rabbit
Category:
Antikörper
Application:
IHC-P, WB
Species Reactivity:
Zebrafish
Immunogen:
An E.coli-derived zebrafish Jab1/COPS5 recombinant protein (amino acids I6-S332) was used as the immunogen for the Zebrafish Jab1 antibody.
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), also known as COPS5 or JAB1, is a gene conserved from humans to Saccharomyces cerevisiae. It is a member of the MOV34 family. COPS5 is mapped to 8q13.1. The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. COPS5 can interact with the cytoplasmic domain of the beta-2 subunit of the alpha-L/beta-2 integrin LFA1, and it is the only protein demonstrated to interact with MIF. COPS5, VHL, and TRC8 proteins appear to be linked both physically and functionally, and all 3 may participate in the development of kidney cancer. In addition to that, COPS5 is an essential cofactor for the apoptotic function of E2F1.
