EML741 also inhibits DNMT1 (IC50, 3.1 µM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barrier penetrated. EML741 is a histone lysine methyltransferase G9a/GLP inhibitor, with an IC50 of 23 nM, Kd of 1.13 µM for G9a.
Molecular Weight:
523.75
CAS Number:
[2328074-38-8]
Formula:
C31H49N5O2
Target:
Histone Methyltransferase
T11185
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