Entacapone sodium salt inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues. Entacapone (< 100 µM) is a potent inhibitor of alpha-syn and beta-amyloid (Abeta) oligomerization and fibrillogenesis, and also protects against extracellular toxicity induced by the aggregation of both proteins in PC12 cells.Entacapone sodium salt is a specific, potent, peripherally acting catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 nM for PD treatment.
Molecular Weight:
328.28
CAS Number:
[1047659-02-8]
Formula:
C14H15N3NaO5
Target:
Others|||Transferase
T11207
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