Ethacrynic acid, a diuretic, functions as an inhibitor of L-type voltage-dependent and store-operated calcium channels, facilitating the relaxation of airway smooth muscle (ASM) cells. It exhibits anti-inflammatory effects, notably reducing retinoid-induced ear edema in mice, and inhibits glutathione S-transferases (GSTs), making it a potent suppressor of the NF-kB signaling pathway. Additionally, ethacrynic acid modulates leukotriene formation. A variant, Ethacrynic acid-D5, is distinguished by its deuterium labeling.
Molecular Weight:
308.17
CAS Number:
[1330052-59-9]
Formula:
C13H12Cl2O4
Target:
Calcium Channel|||NF-kappaB|||GST
T11240
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