F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways.
Molecular Weight:
519.02
Purity:
97.66%
CAS Number:
[2244775-31-1]
Formula:
C22H27ClN8O3S
Target:
ALK|||ROS|||ROS Kinase
T11254
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