FGTI-2734 mesylate, a RAS C-terminal mimetic compound with dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitory activities (IC50s of 250 nM and 520 nM for FT and GGT, respectively), mitigates KRAS resistance by preventing its membrane localization, effectively impeding mutant KRAS patient-derived pancreatic tumors.
Molecular Weight:
606.73
CAS Number:
[2702297-24-1]
Formula:
C27H35FN6O5S2
Target:
Kras|||Others|||Ras|||Transferase
T11282L
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