CRM1 Inhibitor III (Chromosome Region Maintenance 1 Protein Inhibitor III, (Z)-But-2-enedioic acid (4-bromophenyl)amide (3-chlorophenyl)amide, Exportin 1 Inhibitor III, XPO1 Inhibitor III)

Product Overview

• Article Name: CRM1 Inhibitor III (Chromosome Region Maintenance 1 Protein Inhibitor III, (Z)-But-2-enedioic acid (4-bromophenyl)amide (3-chlorophenyl)amide, Exportin 1 Inhibitor III, XPO1 Inhibitor III)
• Biozol Catalog Number: USB-217289
• Supplier Catalog Number: 217289
• Alternative Catalog Number: USB-217289-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A cell-permeable butenediamide compound that acts as a potent, active site cysteine reactive irreversible inhibitor of CRM1/exportin 1. Shown to selectively repress agonist-mediated nuclear export of HDAC4/5, Rev and NFAT proteins in neonatal rat ventricular myocytes (NRVMs, EC50=2.2 and 3.5nM for GFP-HDAC5 and GFP-HIV Rev) and suppress hypertrophic growth of NRVMs (EC50=52nM for ANF expression inhibition) with negligible effect either on the phosphorylation of HDAC5 or on the kinase activities of P and CaMKII at 1uM. Synonyms: (Z)-But-2-enedioic acid (4-bromophenyl)amide (3-chlorophenyl)amide, Chromosome Region Maintenance 1 Protein Inhibitor III, Exportin 1 Inhibitor III, XPO1 Inhibitor III Molecular Formula: C16H12BrClN2O2 Solubility: DMSO (100mg/ml) Purity: 95% (HPLC) Appearance: Supplied as a yellow powder. Storage and Stability: Lyophilized powder may be stored at 4C. Stable for 12 months after receipt at 4C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at 4C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 379.6
• Purity: 95% (HPLC)
• Form: Supplied as a yellow powder.