Artikelnummer: BOT-BNC041592-500

Aurora B (Proliferation Marker)(AURKB/1592), CF405S conjugate, 0.1mg/mL, Clone: [AURKB/1592], Mouse, Monoclonal

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This antibody recognizes a protein of 39 kDa, which is identified as Aurora kinase B (or Aurora B). Aurora B is a serine/threonine protein kinase and component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. It is important for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

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Artikelname:	Aurora B (Proliferation Marker)(AURKB/1592), CF405S conjugate, 0.1mg/mL, Clone: [AURKB/1592], Mouse, Monoclonal
Artikelnummer:	BOT-BNC041592-500
Hersteller-Artikelnummer:	BNC041592-500
Alternativnummer:	BOT-BNC041592-500-500UL
Hersteller:	Biotium
Wirt:	Mouse
Kategorie:	Antikörper
Anwendung:	IHC
Spezies-Reaktivität:	Human
Immunogen:	Recombinant fragment (around aa 89-251) of human Aurora B protein (exact sequence is proprietary)
Konjugation:	CF405S
Alternative Namen:	Aurora kinase B, Aurora B, Aurora-1, AURKB, AIK2, AIM-1, ARK-2, AurB, Aurora and Ipl1 like midbody associated protein 1, Aurora-B, Aurora-related kinase 2, Aurora/IPL1-related kinase 2, IPL1, Protein phosphatase 1 regulatory subunit 48, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase aurora-B, STK1, STK12, STK5

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