Artikelnummer: BOT-BNC400057-100

HLA-DRB(LN-3), CF640R conjugate, 0.1mg/mL, Clone: [LN-3], Mouse, Monoclonal

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This MAb reacts with a 28 kDa chain of HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the LN3 monoclonal antibody, and these antibodies do not cross-block binding to each others respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4 T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

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Artikelname:	HLA-DRB(LN-3), CF640R conjugate, 0.1mg/mL, Clone: [LN-3], Mouse, Monoclonal
Artikelnummer:	BOT-BNC400057-100
Hersteller-Artikelnummer:	BNC400057-100
Alternativnummer:	BOT-BNC400057-100-100UL
Hersteller:	Biotium
Wirt:	Mouse
Kategorie:	Antikörper
Anwendung:	FC, IF, IHC, WB
Spezies-Reaktivität:	Human, Monkey
Immunogen:	Activated human peripheral blood mononuclear cells
Konjugation:	CF640R
Alternative Namen:	DRB1, HLA class II histocompatibility antigen, DR-1 beta chain, HLA-DR-beta 1, HLA-DRB1, human leucocyte antigen DRB1, Leucocyte antigen DR beta 1 chain, lymphocyte antigen DRB1, major histocompatibility complex, class II, DR beta 1, MHC class II HLA-DR beta 1 chain, MHC class II HLA-DR-beta cell surface glycoprotein

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