Produktbeschreibung
The N418 monoclonal antibody reacts with mouse CD11c, the most widely used defining marker for murine dendritic cells (DCs). CD11c is also known as integrin alpha-X (Itgax) and CD11 antigen-like family member C. CD11c is a 150-kDa single-pass type I membrane protein of the integrin alpha chain family, and its related members include CD11a (LFA-1), CD11b (MAC-1), and CD11d (D). In the context of sequence homology, expression profiles, and ligands, CD11c is substantially like CD11b and CD11d. CD11c is expressed on the plasma membranes of most DCs, monocytes, tissue macrophages, NK cells, and at a low level in neutrophils. CD11c binds with cell adhesion molecules (e.g., ICAM-1, ICAM-4), LPS from bacterial cell walls, iC3b complement protein, and fibrinogen, as well as collagen. CD11cs biological functions are not well studied, and pioneering studies showed it to mediate phagocytosis of iC3b-opsonized particles in vitro, which gave it recognition as complement receptor 4 (Cr4). CD11c is suggested to play a role in antigen presentation by the DCs and to mediate inflammatory responses in vivo. Due to its high expression on immature antigen DCs, CD11c is often considered an extremely effective immunotarget in experimental studies. The N418 antibody has also been demonstrated for targeting antigens to DCs (i.e., via CD11c), for rapid antibody generation from low immunogenic antigen targets, for anti-tumoral immunomodulation, and for vaccine strategies. The N418 monoclonal antibody specifically binds on the surface of mouse DCs, and it does not bind peritoneal macrophages, B cells, or lymph node cells. The N418 antibody does not block dendritic cell binding to T cells.
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