Produktbeschreibung
The ACK2 monoclonal antibody reacts with mouse c-Kit also known as CD117, Steel factor receptor, stem cell factor receptor, and mast cell growth factor. c-Kit is a 145 kDa transmembrane tyrosine kinase and an immunoglobulin superfamily member. c-Kit is expressed on hematopoietic progenitor cells, mast cells, and acute myeloid leukemia (AML) cells. The interaction of the c-Kit receptor and its ligand stem cell factor (SCF), promotes the proliferation and differentiation of hematopoietic progenitor cells. The ACK2 antibody has been reported to deplete c-Kit+ cells, including mast cells, when administered in vivo and neutralize c-Kit+ signaling when used in vitro. This antibody is reported to cross-react with rat c-Kit.
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