Artikelnummer: BXC-BE0310-INDUSTRIAL

InVivoMAb anti-mouse VISTA, Clone: [13F3], Hamster, Monoclonal

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Produktbeschreibung

The 13F3 monoclonal antibody reacts with mouse V-domain Ig suppressor of T cell activation (VISTA) also known as PD-1H and B7-H5. VISTA is a 309 aa type I transmembrane glycoprotein and a member of the Ig superfamily. VISTA is expressed on naive and activated T cells, NK cells, macrophages, dendritic cells, and neutrophils. VISTA functions as a negative immune-checkpoint protein that suppresses T cell cytokine production and proliferation. VISTA is overexpressed by tumor-infiltrating lymphocytes, such as myeloid cells and regulatory T cells. Blockade of VISTA with the 13F3 antibody results in delayed tumor growth in mouse models of melanoma.

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Artikelname:	InVivoMAb anti-mouse VISTA, Clone: [13F3], Hamster, Monoclonal
Artikelnummer:	BXC-BE0310-INDUSTRIAL
Hersteller-Artikelnummer:	BE0310
Alternativnummer:	BXC-BE0310-1MG,BXC-BE0310-5MG,BXC-BE0310-25MG,BXC-BE0310-50MG,BXC-BE0310-100MG
Hersteller:	Bio X Cell
Wirt:	Hamster
Kategorie:	Antikörper
Spezies-Reaktivität:	Mouse
Immunogen:	EL4 cells overexpressing mouse VISTA-RFP and then boosted with VISTA-Ig fusion protein

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