Produktbeschreibung
The 145-2C11 monoclonal antibody reacts with mouse CD3epsilon, a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. CD3epsilon is one of five polypeptide chains that combine to form the TCR complex. CD3epsilon is expressed on T lymphocytes, NK-T cells, and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling, T lymphocyte activation, and antigen recognition. The 145-2C11 antibody has been shown to induce T lymphocyte activation, proliferation, and apoptosis via binding and stimulating the TCR. Additionally, the 145-2C11 antibody has been reported to block the binding of the 17A2 antibody to CD3epsilon+ T lymphocytes.
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