Produktbeschreibung
The 8D3 monoclonal antibody reacts with mouse CD71 also known as transferrin receptor protein 1 (TfR1). CD71 is a 170-180 kDa type II homodimeric transmembrane glycoprotein which is expressed on the surface of proliferating cells, reticulocytes, and erythroid precursors. CD71 plays a role in the control of cellular proliferation and is required for iron import from transferrin into cells by endocytosis. CD71 is expressed on malignant cells at high levels and its expression correlates with cancer progression. This high expression on malignant cells along with CD71s ability to internalize, and the necessity of iron for cancer cell proliferation make the transferrin receptor an attractive target to exploit for the delivery of drugs into malignant cells. The 8D3 antibody has been shown to deplete CD71+ cells in vivo. Bio X Cell is pleased to offer recombinant versions of the original 8D3 antibody, 8D3-CP055 and 8D3-CP078. The 8D3-CP055 monoclonal antibody is a murine chimeric version of the original 8D3 antibody with the constant regions converted to mouse IgG2a, kappa for use in murine models. Additionally, murine chimeric 8D3-CP078 contains LALA-PG mutations in the mouse IgG2a heavy chain rendering it unable to bind endogenous murine Fcgamma receptors or C1q to induce antibody-dependent, cell-mediated cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC). Species-matched chimeric antibodies exhibit regulated effector functions and result in less immunogenicity and formation of anti-drug antibodies (ADAs) than xenogenic antibodies in animal models. The highly controlled sequence and lack of genetic drift in recombinant antibodies provide more reliable and reproducible results over hybridoma derived antibodies.
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