Arecoline HBr, CAS [[300-08-3]]

Produktübersicht

• Artikelname: Arecoline HBr, CAS [[300-08-3]]
• Artikelnummer: FBM-10-1016
• Hersteller Artikelnummer: 10-1016
• Alternativnummer: FBM-10-1016-250MG,FBM-10-1016-1G
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

ACAT1 inhibitor

Produkteigenschaften

• Molekulargewicht: 236.11
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [300-08-3]
• Formel: C8H13NO2 HBr

Anwendungsbeschreibung

• Anwendungsbeschreibung: Tyrosine407 phosphorylation activates mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) by stabilizing its tetramer. This is believed to be the mechanisms by which ACAT1 is ''hijacked and contributes to the Warburg effect in cancer. Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50=11.1 µM). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass.1 Agonist at muscarinic acetylcholine receptors M1 - M5 (EC50 in the range of 7-410 nM).2 May be effective in dementia.3