BMS-833923, CAS [[1059734-66-5]]

Produktübersicht

• Artikelname: BMS-833923, CAS [[1059734-66-5]]
• Artikelnummer: FBM-10-3049
• Hersteller Artikelnummer: 10-3049
• Alternativnummer: FBM-10-3049-5MG, FBM-10-3049-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-(2-Methyl-5-((methylamino)methyl)phenyl)-4-((4-phenylquinazolin-2-yl)amino)benzamide. Alternate Names: XL-139

Produktbeschreibung

SMO antagonist

Produkteigenschaften

• Molekulargewicht: 473.58
• Reinheit: >98% by HPLC, NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [1059734-66-5]
• Formel: C30H27N5O

Anwendungsbeschreibung

• Anwendungsbeschreibung: BMS-833923 (1059734-66-5) is a smoothened (SMO) antagonist. It decreased cell proliferation and induced apoptosis (EC50=10 mM) via the intrinsic pathway in esophageal adenocarcinoma cell lines.1 Ameloblastoma cells with an activating SMO-L412F mutation were insensitive to vismodegib (another SMO antagonist) but BMS-833923 significantly reduced downstream Hedgehog signaling and tumor cell viability.2 In developmental studies BMS-833923 has been characterized as a uniquely effective SMO inhibitor when it was used to show that Sonic hedgehog is functionally dedicated to ray branching during fin regeneration in zebrafish.3 Orally active.