Chemical Name: N-[(1S)-2-[[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide. Alternate Names: gamma-Secretase Inhibitor XXI, Cpd E
Gamma secretase inhibitor
Molekulargewicht:
490.51
Reinheit:
98% by TLC NMR (Conforms)
Formulierung:
White solid
CAS Nummer:
[209986-17-4]
Formel:
C27H24F2N4O3
Anwendungsbeschreibung:
Compound E (209986-17-4) is a potent and selective, cell permeable inhibitor of gamma-secretase which inhibits the cleavage of both amyloid precursor protein and Notch, IC50s ~ 3 nM.1,2 Inhibits growth and induces differentiation of neuroblastoma cells.3 Induces stem cell neuronal differentiation.4
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