PY-60, CAS [[2765218-56-0]]

Produktübersicht

• Artikelname: PY-60, CAS [[2765218-56-0]]
• Artikelnummer: FBM-10-3924
• Hersteller Artikelnummer: 10-3924
• Alternativnummer: FBM-10-3924-5MG, FBM-10-3924-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 5-Phenyl-N-[3-(1,3-thizol-2-yl)propyl]-1,2-oxazole-3-carboxamide

Produktbeschreibung

YAP Activator

Produkteigenschaften

• Molekulargewicht: 313.38
• Reinheit: >98% by HPLC , NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [2765218-56-0]
• Formel: C16H15N3O2S

Anwendungsbeschreibung

• Anwendungsbeschreibung: PY-60 (2765218-56-0) activates YAP transcriptional activity (EC50 = 1.6 µM) via delocalization of annexin A2 (ANXA2) from cell membranes leading to Hippo inactivation, a key controller of YAP.1 It was able to induce serum-free expansion of MCF10A cells and epidermal keratinocytes and their precursors ex vivo and in adult mice. PY-60 promoted regenerative repair of cutaneous wounds in pig and human models by enabling a pro-proliferative transcriptional program in keratinocytes and dermal cells that accelerated re-epithelization and regranulation of the wound bed.2