Chemical Name: (3S)-3-[[(2S)-2-[[2-(2-tert-butylanilino)-2-oxoacetyl]amino]propanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid. Alternate Names: IDN-6556, PF-03491390
pan-Caspase inhibitor
Molekulargewicht:
569.51
Reinheit:
98% by HPLC, NMR (Confirms)
Formulierung:
White solid
CAS Nummer:
[254750-02-2]
Formel:
C26H27F4N3O7
Anwendungsbeschreibung:
Emricasan is a liver-targeted antiapoptotic pan-caspase inhibitor.1,2 It has been investigated as a hepatoprotective agent in the treatment of liver ischemia3 and NASH/NAFLD liver injury4,5. Emricasan protected SNB-19 cells against cell death induced by Zika virus strains MR766, FSS13025, and PRVABC59.6 Emricasan improves the viability of hPSCs and their differentiated progeny when used in a small molecule cocktail (CEPT) containing chroman 1, polyamines and trans-ISRIB.7
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