K-975, CAS [[2563855-03-6]]

Produktübersicht

• Artikelname: K-975, CAS [[2563855-03-6]]
• Artikelnummer: FBM-10-4297
• Hersteller Artikelnummer: 10-4297
• Alternativnummer: FBM-10-4297-1MG,FBM-10-4297-5MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

YAP/TAZ-TEAD signaling inhibitor

Produkteigenschaften

• Molekulargewicht: 287.74
• Reinheit: >98% by HPLC, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [2563855-03-6]
• Formel: C16H14ClNO2

Anwendungsbeschreibung

• Anwendungsbeschreibung: K-975 is a covalent inhibitor of YAP/TAZ-TEAD signaling. It binds to the palmitate-binding pocket of TEAD preventing its association with YAP/TAZ.1 K-975 inhibited proliferation of NF2-non-expressing mesothelioma cell lines. K-975 promoted liver progenitor cell to hepatocyte differentiation via suppression of YAP signaling.2 It sensitized YAP-expressing RET-aberrant cancer cells to RET kinase inhibitors.3