Wnt-C59, CAS [[1243243-89-1]]

Produktübersicht

• Artikelname: Wnt-C59, CAS [[1243243-89-1]]
• Artikelnummer: FBM-10-4605
• Hersteller Artikelnummer: 10-4605
• Alternativnummer: FBM-10-4605-5MG,FBM-10-4605-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

Porcupine inhibitor

Produkteigenschaften

• Molekulargewicht: 379.46
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: Tan Solid
• CAS Nummer: [1243243-89-1]
• Formel: C25H21N3O

Anwendungsbeschreibung

• Anwendungsbeschreibung: Wnt-C59 is a potent (IC50 = 74 pmol/L) inhibitor of Porcupine (PORCN), a Wnt-acyltransferase. Blockage of Wnt-acyltransferase prevents secretion of all Wnt isoforms. It was able to block progression of mammary tumors in MMTV-WNT1 transgenic mice.1 Wnt-C59 strongly inhibited the growth of intestinal neoplasia in RZ-mutant mice. Wnt-C59 was able to efficiently differentiate pluripotent stem cells into cortical neurons (CTIP2+/COUP-TF1). Wnt-C59 was also able to dramatically attenuate kidney fibrosis via inhibition of collagen mRNA expression and expression of inflammatory cytokines.