Senexin B, CAS [[1449228-40-3]]

Produktübersicht

• Artikelname: Senexin B, CAS [[1449228-40-3]]
• Artikelnummer: FBM-10-4863
• Hersteller Artikelnummer: 10-4863
• Alternativnummer: FBM-10-4863-5MG, FBM-10-4863-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 4-[2-[6-(4-Methylpiperazine-1-carbonyl)naphthalen-2-yl]ethylamino]quinazoline-6-carbonitrile. Alternate Names: BCD-115, SenB

Produktbeschreibung

CDK8/19 inhibitor

Produkteigenschaften

• Molekulargewicht: 450.55
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [1449228-40-3]
• Formel: C27H26N6O

Anwendungsbeschreibung

• Anwendungsbeschreibung: Senexin B is a potent inhibitor of cyclin-dependent kinases 8 and 19.1 It suppressed tumor growth and augmented the effects of fulvestrant in ER-positive breast cancer xenografts. KD50s: CDK8 = 59 nM, CDK19 = 23 nM.2 Senexin B also showed synergistic effects with lapatinib and trastuzumab in a panel of HER2+ breast cancer cell lines. Senexin B and ALK5 inhibitor SB431542 afforded generation of pancreatic islet cells from pluripotent stem cells without any mutagenic effects.4 Combination treatment of Senexin B and Imatinib intensified apoptotic cell death in chronic myelogenous leukemia cells and prevented quiescence-mediated escape from apoptosis.5