Chemical Name: 4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-N-8-quinolinyl-benzamide
Wnt signaling inhibitor
Molekulargewicht:
409.44
Reinheit:
98% by TLC/HPLC NMR (Conforms)
Formulierung:
Off white or yellow solid
CAS Nummer:
[1127442-82-3]
Formel:
C25H19N3O2
Anwendungsbeschreibung:
A potent inhibitor of Wnt signaling (IC50=180 nM).1 Inhibits zebrafish tailfin regeneration (0.5 mM).2 Acts via inhibition of tankyrase and attenuates Wnt/b-catenin signaling in cancer stem-like cells.3 Promotes self-renewal and maintains pluripotency of human embryonic stem cells.4 Promotes differentiation of pluripotent stem cells into cardiomyocytes.5
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