Stimulates human beta-cell proliferation both in a dispersed islet proliferation assay and in intact human cultures.1 It has been shown to induce both alpha- and beta-cell proliferation.2 May lead to the development of new therapeutics for diabetes.3 Induces adult hippocampal neurogenesis correlating with its antidepressant effect in a rat model of chronic unpredictable mild stress-induced depression.4 Has been used together with TTNPB and azakenpaullone, as a defined chemical cocktail to induce mouse totipotent stem cells.5 Cell permeable.
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