SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [CR3022], IgG1, Unconjugated, Human, Monoclonal
Artikelnummer:
GTX01555
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| Artikelname: | SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [CR3022], IgG1, Unconjugated, Human, Monoclonal |
| Artikelnummer: | GTX01555 |
| Hersteller Artikelnummer: | GTX01555 |
| Alternativnummer: | GTX01555-100 |
| Hersteller: | GeneTex |
| Wirt: | Human |
| Kategorie: | Antikörper |
| Applikation: | ELISA, NeA |
| Spezies Reaktivität: | Virus |
| Immunogen: | The original monoclonal antibody was generated by sequencing peripheral blood lymphocytes of a patient exposed to the SARS-CoV. |
| Konjugation: | Unconjugated |
| Alternative Synonym: | 2019-nCoV Spike, COVID-19 Spike, SARS-CoV-2 Spike, covid-19, sars-cov, sars-cov-2 |
| SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [CR3022] binds to both SARS-CoV and SARS-CoV-2 with high affinity (PMID: 16796401 & 32065055). The initial characterization of the binding of this antibody was performed by ELISA and indicates potential for the development of diagnostic assays, as both virus-capture assays, or as controls in serological assays measuring immune responses to virus exposure. The original human IgG1 version of the antibody works synergistically in combination with another non-competing SARS antibody CR3014 and is a potential candidate for passive immune prophylaxis of SARS-CoV infection (ter Meulen et al., 2006). The original antibody (human IgG1) was also reported to bind the SARS-CoV-2 RBD (KD of 6.3 nM). This antibody may have potential as a therapeutic agent, alone or in combination with other neutralizing antibodies for treatment of SARS-CoV-2 infections (Tian et al., 2020). |
| Klonalität: | Monoclonal |
| Konzentration: | 1 mg/ml (Please refer to the vial label for the specific concentration.) |
| Klon-Bezeichnung: | [CR3022] |
| Isotyp: | IgG1 |
| Sensitivitaet: | This antibody binds the amino acids 318-510 in the S1 domain of the SARS-CoV Spike protein as well as SARS-CoV-2 (COVID-19) Spike protein. The antibody also binds to P462L-substituted S318-510 fragments of the SARS spike protein. The binding epitope is on |
| NCBI: | 1489668 |
| UniProt: | P59594 |
| Puffer: | PBS, 0.02% ProClin 300. |
| Reinheit: | Protein A purified |
| Formulierung: | Liquid |
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