Human Type I Interferon Neutralizing Antibody Mixture, Unconjugated, Polyclonal

Artikelnummer: PBL-39000-1
Artikelname: Human Type I Interferon Neutralizing Antibody Mixture, Unconjugated, Polyclonal
Artikelnummer: PBL-39000-1
Hersteller Artikelnummer: 39000-1
Alternativnummer: PBL-39000-1
Hersteller: PBL Assay Science
Kategorie: Antikörper
Applikation: NeA
Konjugation: Unconjugated
Human Type I Interferon Neutralizing Antibody Mixture, Unconjugated, Polyclonal 0 ,2 ml

Product Features: 

  • Mixture of monoclonal and polyclonal antibodies directed against human Type 1 Interferons (IFNs) and Type 1 Receptor Subunit 2 (IFNAR2)
  • Effectively neutralizes biological activity of human IFN-alpha, IFN-beta, IFN-omega, IFN-kappa, and IFN-epsilon
  • Improves neutralization of multiple Type I IFNs often found in complex samples by employing a broadly neutralizing custom antibody cocktail
  • Unconjugated

 

Fig: Representative neutralization curves of Human Type I IFN Neutralizing Antibody Mixture (Catalog No. 39000) (diluted 1:50) to human interferon alpha, beta, and omega. In this assay, A549 cells (human lung carcinoma) were incubated with the antibody mixture and titrated interferon, followed by challenging with encephalomyocarditis virus (EMCV).

 

 

Specifications

Formulation Supplied frozen in phosphate-buffered saline (PBS)
Purification A combination of Protein G affinity chromatography and other conventional chromatographical methods.
Endotoxin level < 1 EU/μg
Bioactivity Encephalomyocarditis Virus (EMCV) was used to challenge A549 cells which were incubated with a constant concentration of the antibody mixture and the titrated interferon.
Specificity Blocks biological activity of human Type I interferons (alpha, beta, omega, kappa, epsilon)
No cross reactivity observed with the following human interferons: gamma, lambda 1, lambda 2, lambda 3; or mouse interferons: alpha, beta, gamma
Storage For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles
Synonyms Type I interferon, Type I IFN, Neutralizing, Neutralization, Type I Interferon Receptor, Antibody Cocktail
Klonalität: Polyclonal
Puffer: Phosphate - buffered saline (PBS)
Representative neutralization curves of Human Type I IFN Neutralizing Antibody Mixture (Catalog No. 39000) (diluted 1:50) to human interferon alpha, beta, and omega.