Human Type I Interferon Neutralizing Antibody Mixture, Unconjugated, Polyclonal
PBL Assay Science
Human Type I Interferon Neutralizing Antibody Mixture, Unconjugated, Polyclonal 0 ,2 ml
Mixture of monoclonal and polyclonal antibodies directed against human Type 1 Interferons (IFNs) and Type 1 Receptor Subunit 2 (IFNAR2)
Effectively neutralizes biological activity of human IFN-alpha, IFN-beta, IFN-omega, IFN-kappa, and IFN-epsilon
Improves neutralization of multiple Type I IFNs often found in complex samples by employing a broadly neutralizing custom antibody cocktail
Fig: Representative neutralization curves of Human Type I IFN Neutralizing Antibody Mixture (Catalog No. 39000) (diluted 1:50) to human interferon alpha, beta, and omega. In this assay, A549 cells (human lung carcinoma) were incubated with the antibody mixture and titrated interferon, followed by challenging with encephalomyocarditis virus (EMCV).
Supplied frozen in phosphate-buffered saline (PBS)
A combination of Protein G affinity chromatography and other conventional chromatographical methods.
Endotoxin level < 1 EU/μg
Encephalomyocarditis Virus (EMCV) was used to challenge A549 cells which were incubated with a constant concentration of the antibody mixture and the titrated interferon.
Blocks biological activity of human Type I interferons (alpha, beta, omega, kappa, epsilon)
No cross reactivity observed with the following human interferons: gamma, lambda 1, lambda 2, lambda 3; or mouse interferons: alpha, beta, gamma
For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles
Type I interferon, Type I IFN, Neutralizing, Neutralization, Type I Interferon Receptor, Antibody Cocktail
Phosphate - buffered saline (PBS)
Representative neutralization curves of Human Type I IFN Neutralizing Antibody Mixture (Catalog No. 39000) (diluted 1:50) to human interferon alpha, beta, and omega.
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